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answers.comMethylation been discovered on a spread of lysine residues in varied histones: K4 (using the one-letter amino-acid code for lysine), K9, K27, K36 and K79 in histone H3, K20 in histone H4, K59 within the globular domain of histone H4 2 and K26 of histone H1B three Several proteins chargeable for the methylation of particular residues have been characterised, and all however certainly one of these contains a SET domain